Diabetes mellitus is one of the aggressive disorders in global society. No pharmacotherapy is available for permanent diabetes cure, although management is possible with drugs and physical activities. One of the recent complications noticed in type 2 diabetes mellitus includes diabetes-induced Alzheimer. It has been proposed that the possible diabetes-induced Alzheimer could be of type 3 diabetes. A variety of cross-sectional studies have proved that type 2 diabetes mellitus is one of the factors responsible for the pathophysiology of Alzheimer. New drug molecules developed by pharmaceutical companies with adequate neuroprotective effect have demonstrated their efficacy in treatment of Alzheimer in various preclinical diabetic studies. Patients of type 2 diabetes mellitus may show the benefit with existing drugs but may not cause complete cure. Extensive studies are being carried out to find new drug molecules that show their potential as antidiabetic drug and could treat type 2 diabetes–induced Alzheimer as well. This review provides an overview about the recent advancement in pharmacotherapy of diabetes-induced Alzheimer. The pathomechanistic links between diabetes and Alzheimer as well as neurochemical changes in diabetes-induced Alzheimer are also briefed.

糖尿病是全球社会的侵略性疾病之一。尽管可以通过药物和体育锻炼进行治疗，但无法采用药物疗法来永久治愈糖尿病。在2型糖尿病中发现的近期并发症之一包括糖尿病引起的阿兹海默症。已经提出，可能由糖尿病引起的阿尔茨海默氏症可能是3型糖尿病。各种横断面研究已证明2型糖尿病是导致阿尔茨海默氏症病理生理的因素之一。由制药公司开发的具有足够的神经保护作用的新药物分子在各种临床前糖尿病研究中已证明其可治疗阿尔茨海默氏症。2型糖尿病患者可能会显示使用现有药物的益处，但可能无法完全治愈。正在进行广泛的研究以发现新的药物分子，这些分子显示出其作为抗糖尿病药的潜力，并且还可以治疗2型糖尿病诱发的阿尔茨海默氏病。这篇综述概述了糖尿病引起的阿尔茨海默氏症药物治疗的最新进展。还简要介绍了糖尿病和阿尔茨海默氏症之间的致病机理联系以及糖尿病引起的阿尔茨海默氏症的神经化学变化。