Rhodium(III)-catalyzed enantioselective oxidative C-H/C-H cross-coupling reaction between two arenes is disclosed. With the combination of a chiral CpRh(III) complex and a chiral carboxylic acid additive, the direct coupling reactions between 1-aryl isoquinoline derivatives and electron-rich heteroarenes such as thiophenes, furans, benzothiophenes, benzofurans are realized via a double C-H functionalization process. A series of axially chiral compounds are obtained in excellent yields and enantioselectivities (up to 99% yield and 99% ee). Mechanistic studies suggest that both C-H bond cleavages may not be the turnover-limiting step.

中文翻译：

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铑催化的 1-芳基异喹啉衍生物与富电子杂芳烃的阻转选择性氧化 CH/CH 交叉偶联反应

公开了铑(III)-催化的两种芳烃之间的对映选择性氧化CH/CH交叉偶联反应。通过手性 CpRh(III) 配合物和手性羧酸添加剂的结合，1-芳基异喹啉衍生物与富电子杂芳烃如噻吩、呋喃、苯并噻吩、苯并呋喃之间的直接偶联反应是通过双 CH 官能化过程实现的. 以优异的产率和对映选择性（高达 99% 的产率和 99% ee）获得了一系列轴向手性化合物。机理研究表明，两个 CH 键裂解可能不是周转限制步骤。