Angelica Sinensis Radix (Danggui, DG) is one of the most commonly prescribed traditional Chinese medicines. The organic components include phthalides and phenolic acids. Meanwhile, inorganic elements play an important role in clinical effect. DG and its different parts have different effects. There is no relevant report on the analysis of organic compounds and inorganic elements among them. Therefore, ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed for the simultaneous determination of 13 organic components (8 phthalides and 5 phenolic acids), and 8 inorganic elements were determined by inductively coupled plasma mass spectrometry. The contents of 32 samples were analyzed by orthogonal partial least squares discrimination analysis, hierarchical cluster analysis, and least-significant difference of one-way analysis of variance. The results showed that the differences were significant among DG and its different parts. 11 difference markers (Ca, Z-ligustilide, Mg, Mn, Fe, Na, K, Cu, Zn, coniferyl ferulate, and senkyunolide A) were obtained by variable importance for the project. These difference markers were some different among DG and its different parts, especially Z‐ligustilide, coniferyl ferulate, Mg, Zn, the differences were significant. This study can provide a reference for DG research.

中文翻译：

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结合化学识别模式对当归及其不同部位13种有机成分和8种无机元素的定量分析

当归（当归，DG）是最常用的处方中药之一。有机成分包括邻苯二甲酸盐和酚酸。同时，无机元素在临床疗效中起着重要作用。DG及其不同部分具有不同的作用。其中没有有关有机化合物和无机元素分析的相关报道。因此，开发了结合三重四极杆质谱的超高效液相色谱仪，用于同时测定13种有机成分（8种邻苯二甲酸盐和5种酚酸），并通过电感耦合等离子体质谱法测定了8种无机元素。通过正交偏最小二乘判别分析，层次聚类分析，32个样本进行分析。和单向方差分析的最小显着差异。结果表明，DG及其不同部分之间存在显着差异。通过该项目的可变重要性，获得了11个差异标记（Ca，Z-轻金属，Mg，Mn，Fe，Na，K，Cu，Zn，针叶树阿魏酸酯和senkyunolide A）。这些差异标记在DG及其不同部位之间存在一些差异，尤其是Z-木脂苷，阿魏针叶树酯，Mg，Zn，差异是显着的。该研究可为DG研究提供参考。这些差异标记在DG及其不同部位之间存在一些差异，尤其是Z-木脂苷，阿魏针叶树酯，Mg，Zn，差异是显着的。该研究可为DG研究提供参考。这些差异标记在DG及其不同部位之间存在一些差异，尤其是Z-木脂苷，阿魏针叶树酯，Mg，Zn，差异是显着的。该研究可为DG研究提供参考。