Abstract

A new prenylated coumarin diglycoside, 6-prenylcoumarin-7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and five known flavonoid glycosides (2–6) were isolated from the leaves and stems of Clausena dunniana. The structures of these isolates were elucidated based on comprehensive MS, UV, IR, and NMR spectroscopic data analysis and comparison with the data reported in literature. Compounds 2–6 are obtained from the title plant for the first time. All these isolates were evaluated for their insulin-release promoting effects, and compounds 1, 2, and 4 exhibited significant activities (2.0 to 3.3-fold higher in comparison with the control, p < 0.01) at 40 μM.

摘要

一种新的异戊烯化的香豆素二糖苷，6-prenylcoumarin -7- ø - β -D- apiofuranosyl-（1→6） - β -D-吡喃葡糖苷（1）和5节已知黄酮苷（2-6）从叶中分离和Clausena dunniana的茎。根据全面的MS，UV，IR和NMR光谱数据分析并与文献报道的数据进行比较，阐明了这些分离物的结构。化合物2-6首次从标题植物中获得。所有这些菌株为他们的胰岛素释放促进作用进行了评价，和化合物1，2，和4 在40μM时显示出显着的活性（与对照相比，高2.0至3.3倍，p <0.01）。