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Antibody detection assays for COVID-19 diagnosis: an early overview.
Immunology and Cell Biology ( IF 4 ) Pub Date : 2020-08-30 , DOI: 10.1111/imcb.12397
Sarfaraz Ahmad Ejazi 1 , Sneha Ghosh 1, 2 , Nahid Ali 1
Affiliation  

The ongoing pandemic of coronavirus disease 2019 (COVID‐19) has not only commenced a global health emergency but also agitated various aspects of humanity. During this period of crisis, researchers over the world have ramped their efforts to constrain the disease in all possible ways, whether it is vaccination, therapy or diagnosis. Because the spread of the disease has not yet elapsed, sharing the ongoing research findings could be the key to disease control and management. An early and efficient diagnosis could leverage the outcome until a successful vaccine is developed. Both in‐house and commercial kits are the preferred molecular tests being used worldwide in the COVID‐19 diagnosis. However, the limitation of high prices and lengthy procedures impede their use for mass testing. Keeping the constant rise of infection in mind, the search for an alternative test that is cost‐effective, simple and suitable for large‐scale testing and surveillance is the need of the hour. One such alternative could be immunological tests. In the last few months, a deluge of immunological rapid tests have been developed and validated across the globe. The objective of this review is to share the diagnostic performance of various immunological assays reported so far in severe acute respiratory syndrome coronavirus 2 case detection. We consolidate the studies (published and preprints) related to serological tests such as chemiluminescence, enzyme‐linked and lateral flow‐based point‐of‐care tests in COVID‐19 diagnosis and update the current scenario. This review aims to be an add‐on in COVID‐19 research and will contribute to congregation of the evidence for decision making.

中文翻译:

用于COVID-19诊断的抗体检测方法:早期概述。

持续不断的2019年冠状病毒疾病大流行(COVID-19)不仅引发了全球卫生紧急情况,而且激怒了人类的各个方面。在危机期间,世界各地的研究人员加大了以各种可能的方式来控制疾病的努力,无论是疫苗,治疗还是诊断。由于疾病的传播尚未过去,因此共享正在进行的研究结果可能是疾病控制和管理的关键。早期而有效的诊断可以利用结果,直到开发出成功的疫苗为止。内部和商业工具包都是在COVID-19诊断中全球首选的分子检测方法。但是,高价格和冗长程序的局限性限制了它们在大规模测试中的使用。考虑到感染的持续上升,迫切需要一个经济高效,简单且适合大规模测试和监视的替代测试。一种这样的替代方法可以是免疫学测试。在过去的几个月中,全球范围内开发并验​​证了大量的免疫学快速测试方法。这篇综述的目的是分享迄今为止报道的在严重急性呼吸系统综合症冠状病毒2例检测中的各种免疫学测定方法的诊断性能。我们在COVID-19诊断中整合了与血清学检测有关的研究(已发表和预印本),例如化学发光,酶联和侧流即时检验等,并更新了当前情况。这次审查旨在成为COVID-19研究的补充,并将有助于为决策提供证据。
更新日期:2020-08-30
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