Small‐conductance Ca²⁺‐activated potassium (SK) channels are activated exclusively by increases in intracellular Ca²⁺ that binds to calmodulin constitutively associated with the channel. Wild‐type SK2 channels are activated by Ca²⁺ with an EC₅₀ value of ~0.3 μmol/L. Here, we investigate hydrophobic interactions between the HA helix and the S4‐S5 linker as a major determinant of channel apparent Ca²⁺ sensitivity.

中文翻译：

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HA 螺旋和 S4-S5 连接体之间的疏水相互作用调节 SK2 通道的表观 Ca2+ 敏感性。

小电导 Ca ^{2+激活钾 (SK) 通道仅通过细胞内 Ca 2+}的增加而激活，Ca 2+与通道组成型相关的钙调蛋白结合。野生型 SK2 通道由 Ca ²⁺激活，EC ₅₀值为 ~0.3 μmol/L。^{在这里，我们研究了 HA 螺旋和 S4-S5 连接体之间的疏水相互作用，作为通道表观 Ca 2+}敏感性的主要决定因素。