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Evaluation of in vitro corrosion behavior of zinc-hydroxyapatite and zinc-hydroxyapatite-iron as biodegradable composites.
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.4 ) Pub Date : 2020-08-31 , DOI: 10.1002/jbm.b.34712
Dayanidhi Krishana Pathak 1 , Pulak Mohan Pandey 1
Affiliation  

Zinc (Zn) based biomaterials have been emerged as one of the capable biodegradable materials for biomedical applications because of the ideal degradation properties. In the present work, corrosion kinetics of Zn–hydroxyapatite (HA), and Zn–HA–iron (Fe) materials developed using microwave sintering process were investigated. The effect of the inclusion of HA and Fe in Zn on corrosion properties have been evaluated in the simulated body fluid solution. Further, the wettability test of the developed composites was performed to confirm the hydrophilic nature of the surface of all samples. Zn‐3HA was found to have better hydrophilicity as compared to other samples. Increased corrosion rate and pH of Zn‐5HA‐2Fe samples were attributed to the addition of HA and Fe in the Zn matrix. The corrosion rate and weight loss rate from electrochemical and immersion testing of all samples were found in the order from highest to lowest: Zn‐5HA‐2Fe > Zn‐3HA > Zn‐3HA‐2Fe > Zn. The highest cell viability nearly 100% was obtained for Zn‐3HA samples, whereas other samples also showed sufficient biocompatibility to be utilized for biomedical applications.

中文翻译:

评价锌-羟基磷灰石和锌-羟基磷灰石-铁作为可生物降解复合材料的体外腐蚀行为。

锌 (Zn) 基生物材料由于具有理想的降解特性,已成为生物医学应用中具有能力的可生物降解材料之一。在目前的工作中,研究了使用微波烧结工艺开发的 Zn-羟基磷灰石 (HA) 和 Zn-HA-铁 (Fe) 材料的腐蚀动力学。已在模拟体液溶液中评估了在 Zn 中加入 HA 和 Fe 对腐蚀特性的影响。此外,对开发的复合材料进行了润湿性测试,以确认所有样品表面的亲水性。与其他样品相比,Zn-3HA 被发现具有更好的亲水性。Zn-5HA-2Fe 样品的腐蚀速率和 pH 值增加归因于在 Zn 基体中添加 HA 和 Fe。所有样品的电化学和浸泡测试的腐蚀速率和失重率从高到低的顺序为:Zn-5HA-2Fe > Zn-3HA > Zn-3HA-2Fe > Zn。Zn-3HA 样品的最高细胞活力接近 100%,而其他样品也显示出足够的生物相容性,可用于生物医学应用。
更新日期:2020-08-31
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