Iridium/gold bimetallic peptide bioconjugates are presented as a new source of theranostic agents. This work provides crucial insight into the factors that contribute to anti‐proliferative activity of generally toxic metal fragments in bioconjugates. While chemical tools and reactions exist to link metal fragments to selected sites in peptides almost at will, the exact choice of linker and the resulting coordination environment crucially contribute to the overall activity of the conjugate. More information can be found in the Full Paper by V. Fernández‐Moreira, N. Metzler‐Nolte, M. C. Gimeno, et al. on page 12158.

中文翻译：

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封面：发光双金属IrIII / AuI肽生物共轭物作为潜在的治疗剂（Chem。Eur。J. 53/2020）

铱/金双金属肽生物缀合物被提出作为治疗试剂的新来源。这项工作提供了关键因素的洞察力，这些因素有助于生物缀合物中一般有毒金属碎片的抗增殖活性。尽管存在化学工具和反应，几乎可以随意将金属片段连接到肽中的选定位点，但连接子的正确选择和产生的配位环境对缀合物的整体活性至关重要。V.Fernández-Moreira，N。Metzler-Nolte，M.C。Gimeno等人在《全文》中可以找到更多信息。在第12158页。