The important role of lncRNAs and miRNAs in directing immune responses has become increasingly clear. Recent evidence conforms that miRNAs and lncRNAs are involved in NK cell biology and diseases through RNA–protein, RNA–RNA, or RNA–DNA interactions. In this view, we summarize the contribution of miRNAs and lncRNAs to NK cell lineage development, activation and function, highlight the biological significance of functional miRNAs or lncRNAs in NKTL and discuss the potential of these miRNAs and lncRNAs as innovative biomarkers/targets for NKTL early diagnosis, target treatment and prognostic evaluations.

lncRNA和miRNA在指导免疫反应中的重要作用已经变得越来越清楚。最近的证据表明，miRNA 和 lncRNA 通过 RNA-蛋白质、RNA-RNA 或 RNA-DNA 相互作用参与 NK 细胞生物学和疾病。在这个观点中，我们总结了 miRNA 和 lncRNA 对 NK 细胞谱系发育、激活和功能的贡献，强调了功能性 miRNA 或 lncRNA 在 NKTL 中的生物学意义，并讨论了这些 miRNA 和 lncRNA 作为 NKTL 早期创新生物标志物/靶点的潜力。诊断、靶向治疗和预后评估。