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The alkoxycarbonylation of protected propargyl alcohols
Molecular Catalysis ( IF 4.6 ) Pub Date : 2020-08-31 , DOI: 10.1016/j.mcat.2020.111179
R. Sole , A. Scrivanti , M. Bertoldini , V. Beghetto , Md. Mahbubul Alam

Palladium-catalyzed alkoxycarbonylation of the C≡C triple bond of propargyl alcohol is a sustainable synthetic approach to 2-(hydroxymethyl)acrylates, a family of valuable intermediates. The developed synthetic protocol includes protection of the alcoholic function of the alkyne before its carbonylation in the presence of Drent’s catalytic system. Protection step effectively extends the catalyst life hence enhancing the practical applicability of the reaction. The effectiveness of some different protecting groups (benzyl, acetyl and trimethylsilyl) has been assessed and the influence of the reaction parameters investigated.



中文翻译:

被保护的炔丙醇的烷氧羰基化

炔丙基醇的C≡C三键的钯催化烷氧羰基化是一种可持续的合成方法,用于合成2-(羟甲基)丙烯酸酯(一种有价值的中间体)。所开发的合成方案包括在Drent催化系统存在下保护炔烃羰基化之前的醇功能。保护步骤有效地延长了催化剂寿命,从而提高了反应的实际适用性。评估了一些不同保护基(苄基,乙酰基和三甲基甲硅烷基)的有效性,并研究了反应参数的影响。

更新日期:2020-08-31
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