Background

Chromium picolinate (CrPic) and vitamin D3 are known as two antioxidant micronutrients. Through inducing endothelial dysfunction, oxidants such as homocysteine (Hct) and malondialdehyde (MDA) lead to cardiovascular disease in type 2 diabetes mellitus (T2DM). No published data has directly examined the effects of these two antioxidants on improving the endothelial dysfunction in T2DM throughreducing homocysteine and oxidative stress.

Methods

Subjects (n = 92) in this randomized, double blind, placebo-control study were randomly assigned to receive oral placebo (group I), D₃ (group II: 50,000 IU/ week), chromium picolinate (CrPic) (group III: 500 μg/day), and both vitamin D₃ and CrPic (group IV) for four months. Fasting blood samples were drawn at study baseline and following intervention to determine Hct, MDA, total antioxidant capacity (TAC), total thiol groups (SHs), vascular cell adhesion molecule- 1 (VCAM-1), and plasminogen activator inhibitor-1 (PAI-1).

Results

After intervention, MDA significantly decreased in groups II and IV; TAC significantly increased in group IV, and SHs significantly augmented in group III; Hct was significantly reduced in groups II, III, and IV; and VCAM-1 significantly decreased in groups III and IV and PAI-1 was significantly reduced in groups II, III, and IV.

Conclusion

Our findings suggest that through reducing homocysteine and oxidative stress and improving endothelial dysfunction, chromium and vitamin D₃ co-supplementation might be predictive and preventive of cardiovascular diseasesassociated with T2DM.

IRCT, IRCT20190610043852N1, registered 21 October 2019, https://fa.irct.ir/user/trial/42293/view

中文翻译：

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用铬和维生素 D3 通过减少同型半胱氨酸和氧化应激来改善 2 型糖尿病的内皮功能障碍：一项随机安慰剂对照试验

背景

吡啶甲酸铬 (CrPic) 和维生素 D3 被称为两种抗氧化微量营养素。通过诱导内皮功能障碍，高半胱氨酸 (Hct) 和丙二醛 (MDA) 等氧化剂导致 2 型糖尿病 (T2DM) 的心血管疾病。没有公开的数据直接检查这两种抗氧化剂通过减少同型半胱氨酸和氧化应激对改善 T2DM 内皮功能障碍的影响。

方法

这项随机、双盲、安慰剂对照研究中的受试者 ( n = 92) 被随机分配接受口服安慰剂（I 组）、D ₃（II 组：50,000 IU/周）、吡啶甲酸铬 (CrPic)（III 组： 500 μg/天），以及维生素 D ₃和 CrPic（IV 组）四个月。在研究基线和干预后抽取空腹血样以确定 Hct、MDA、总抗氧化能力 (TAC)、总硫醇基团 (SH)、血管细胞粘附分子-1 (VCAM-1) 和纤溶酶原激活剂抑制剂-1。 PAI-1）。

结果

干预后，第二组和第四组的MDA显着下降；IV组TAC显着增加，III组SH显着增加；Hct 在组 II、III 和 IV 中显着降低；VCAM-1在III和IV组中显着降低，PAI-1在II、III和IV组中显着降低。

结论

我们的研究结果表明，通过减少同型半胱氨酸和氧化应激以及改善内皮功能障碍，铬和维生素 D _{3 的}共同补充可能可以预测和预防与 T2DM 相关的心血管疾病。

IRCT，IRCT20190610043852N1，2019年 10 月 21 日注册， https: //fa.irct.ir/user/trial/42293/view