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The differential expression and potential roles of circular RNAs in children with anti-NMDA receptor encephalitis
Journal of Neuroimmunology ( IF 3.3 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.jneuroim.2020.577381
Jiamin Guo 1 , Bo Han 1 , Jing Wang 2 , Li Zhang 3 , Na Chen 1 , Wenxiu Sun 2 , Yuxing Gao 2
Affiliation  

To explore the role of circular RNAs (circRNAs) in pediatric anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, we assessed the profiles of circRNAs and mRNAs in blood leukocytes from anti-NMDA receptor encephalitis patients and healthy controls using microarray analysis. 1196 circRNAs and 719 mRNAs (change ≥2, p < .05) were dysregulated in anti-NMDA receptor encephalitis patients, relative to healthy controls, based on microarray data. Further bioinformatic analysis demonstrated that the host genes of dysregulated circRNAs are primarily associated with receptor internalization. In conclusion, circRNAs may be implicated in the pathogenesis of pediatric anti-NMDA receptor encephalitis.

中文翻译:

环状RNA在抗NMDA受体脑炎患儿中的差异表达及潜在作用

为了探索环状 RNA (circRNA) 在小儿抗 N-甲基-d-天冬氨酸 (NMDA) 受体脑炎中的作用,我们使用微阵列评估了来自抗 NMDA 受体脑炎患者和健康对照的血液白细胞中 circRNA 和 mRNA 的特征分析。根据微阵列数据,相对于健康对照,抗 NMDA 受体脑炎患者中有 1196 个 circRNA 和 719 个 mRNA(变化≥2,p < .05)失调。进一步的生物信息学分析表明,circRNA 失调的宿主基因主要与受体内化有关。总之,circRNAs可能与小儿抗NMDA受体脑炎的发病机制有关。
更新日期:2020-11-01
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