Background/Aims Lymphomas are the most frequent neoplasm of the orbit. However, the epidemiology of orbital lymphomas is not well reported. This study aimed to provide a population-based report on the epidemiology of orbital lymphomas and measure the trends in the incidence of orbital lymphoma cancer in South Korea. Methods Nationwide cancer incidence data from 1999 to 2016 were obtained from the Korea Central Cancer Registry. Age-standardised incidence rates and annual percent changes were calculated according to sex and histological types. The analysis according to the Surveillance, Epidemiology, and End Results summary stage classifications was performed from 2006 to 2016. Survival rates were estimated for cases diagnosed from 1999 to 2016. Results A total of 630 patients (median age: 54 years) with orbital lymphoma in the orbital soft tissue were included in this study. The age-standardised incidence rates increased from 0.03 to 0.08 per 100 000 individuals between 1999 and 2016, with an annual percent change of 6.61%. The most common histopathological type of orbital lymphoma was extra marginal zone B cell lymphoma, accounting for 82.2% of all orbital lymphomas during 1999–2016, followed by diffuse large B cell lymphoma (9.2%). Five-year, 10-year and 15-year overall survival (OS) of orbital lymphoma was 90.8%, 83.8% and 75.8%, respectively. OS showed a significant decrease as age increased and no significant differences between men and women. Conclusion The incidence rate of orbital lymphoma is very low in South Korea. However, the incidence rate has increased over the past years. Orbital lymphomas have a worse prognosis as age increases.

中文翻译：

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韩国 1999 年至 2016 年眼眶淋巴瘤发病率的全国趋势

背景/目的 淋巴瘤是最常见的眼眶肿瘤。然而，眼眶淋巴瘤的流行病学并没有得到很好的报道。本研究旨在提供基于人群的眼眶淋巴瘤流行病学报告，并衡量韩国眼眶淋巴瘤发病率的趋势。方法 从韩国中央癌症登记处获得 1999 年至 2016 年的全国癌症发病率数据。根据性别和组织学类型计算年龄标准化发病率和年度百分比变化。2006 年至 2016 年根据监测、流行病学和最终结果汇总阶段分类进行分析。估计 1999 年至 2016 年诊断的病例的存活率。结果 共有 630 名患者（中位年龄：54 岁）患有眼眶软组织眼眶淋巴瘤的患者被纳入本研究。1999 年至 2016 年间，年龄标准化发病率从每 10 万人 0.​​03 例增加到 0.08 例，年变化百分比为 6.61%。眼眶淋巴瘤最常见的组织病理学类型是边缘区外 B 细胞淋巴瘤，占 1999-2016 年所有眼眶淋巴瘤的 82.2%，其次是弥漫性大 B 细胞淋巴瘤（9.2%）。眼眶淋巴瘤的5年、10年和15年总生存率（OS）分别为90.8%、83.8%和75.8%。OS随着年龄的增长而显着下降，男女之间没有显着差异。结论 韩国眼眶淋巴瘤的发病率很低。然而，发病率在过去几年有所增加。