Rationale: Tumors are commonly treated by resection, which usually leads to massive hemorrhage and tumor cell residues, thereby increasing the risk of local recurrence and distant metastasis./nMethods: Herein, an intelligent 3D-printed poly(lactic-co-glycolic acid), gelatin, and chitosan scaffold loaded with anti-cancer drugs was prepared that showed hemostatic function and good pH sensitivity./nResults: Following in situ implantation in wounds, the scaffolds absorbed hemorrhage and cell residues after surgery, and promoted wound healing. In an in vivo environment, the scaffold responded to the slightly acidic environment of the tumor to undergo sustained drug release to significantly inhibit the recurrence and growth of the tumor, and reduced drug toxicity, all without causing damage to healthy tissues and with good biocompatibility./nConclusions: The multifunctional intelligent scaffold represents an excellent treatment modality for breast cancer following resection, and provides great potential for efficient cancer therapy.

中文翻译：

---

3D打印智能支架可防止乳腺癌的复发和远端转移。

原理：通常通过切除术来治疗肿瘤，这通常会导致大量出血和肿瘤细胞残留，从而增加局部复发和远处转移的风险。/n方法：本文采用智能3D打印的聚乳酸-乙醇酸），明胶和装载抗癌药物支架壳聚糖制备即表明止血功能和良好的pH值sensitivity./n结果：继原位伤口植入支架吸收，出血及细胞残留手术后，促进伤口愈合。在体内在这种环境下，该支架对肿瘤的弱酸性环境作出反应，使其持续释放药物，从而显着抑制了肿瘤的复发和生长，并降低了药物毒性，所有这些都不会对健康组织造成损害并且具有良好的生物相容性./n结论：多功能智能支架代表了切除术后乳腺癌的出色治疗方式，并为有效的癌症治疗提供了巨大潜力。