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The role of circular folds in mixing intensification in the small intestine: A numerical study
Chemical Engineering Science ( IF 4.7 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.ces.2020.116079
Jinping Zha , Siyu Zou , Jianyu Hao , Xinjuan Liu , Guillaume Delaplace , Romain Jeantet , Didier Dupont , Peng Wu , Xiao Dong Chen , Jie Xiao

Abstract The inner wall of the intestine has multiscale structures whose roles, beyond the increase of surface area for absorption, are yet to be discovered. In this study, the mixing process in a human duodenum with circular folds, driven by segmentation contraction, was simulated using a multiphysics model, making it possible to track the evolution of mixing level distributions and enabling quantitative evaluation of the structural role of folds in mixing intensification. It was found that, in a laminar flow regime, circular folds intensify both radial and axial mixing by synergistically offering prominent and long-lasting swirls/vortices, high fluid velocity and high shear rates. Tall and slim folds with enlarged segmentation amplitude, frequency and wavelength can enhance mixing. The maximum enhancement ratio can reach 6.18 under the investigated conditions. These findings will also be valuable for the improved design of biomimetic soft-elastic reactors for the chemical and pharmaceutical industries.

中文翻译:

圆形褶皱在小肠混合强化中的作用:数值研究

摘要 肠道内壁具有多尺度结构,其作用除了增加吸收表面积外,还有待发现。在这项研究中,由分段收缩驱动的具有圆形褶皱的人类十二指肠中的混合过程使用多物理场模型进行模拟,从而可以跟踪混合水平分布的演变,并能够定量评估褶皱在混合中的结构作用集约化。研究发现,在层流状态中,圆形褶皱通过协同提供显着且持久的漩涡/涡流、高流体速度和高剪切速率来加强径向和轴向混合。具有放大分割幅度、频率和波长的细长褶皱可以增强混合。最大增强比可达6。18 在调查条件下。这些发现对于化学和制药行业的仿生软弹性反应器的改进设计也很有价值。
更新日期:2021-01-01
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