Abstract

Nucleophosmin/B23/NPM is a multifunctional protein that regulates the most important processes of cell viability and apoptosis. Disturbances in the NPM gene structure and expression of the B23 protein encoded by this gene play an important role in the development and progression of oncological, neurological, and other diseases. The review considers the structure of the NPM gene and the B23 protein, the functions of nucleophosmin, and its role in carcinogenesis from the standpoint of applied and fundamental molecular biological aspects of modern oncology.

中文翻译：

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核糖蛋白在细胞功能和肿瘤进展中的作用

摘要

Nucleophosmin / B23 / NPM是一种多功能蛋白，可调节细胞活力和凋亡的最重要过程。NPM基因结构的紊乱和该基因编码的B23蛋白的表达在肿瘤，神经系统疾病和其他疾病的发生和发展中起重要作用。综述从现代肿瘤学的应用和基础分子生物学方面出发，考虑了NPM基因和B23蛋白的结构，核磷脂的功能及其在癌变中的作用。