The high death toll of colorectal cancer patients is due to metastatic disease which is difficult to treat. The liver is the preferred site of metastasis, followed by the lungs and peritoneum. In order to identify new targets and new modalities of intervention we surveyed the literature for microRNAs (miRs) which modulate metastasis of colorectal cancer in preclinical in vivo models. We identified 12 up-regulated and 19 down-regulated miRs corresponding to the latter criterium. The vast majority (n=16) of identified miRs are involved in modulation of epithelial-mesenchymal transition (EMT). Other categories of metastasis-related miRs exhibit tumor- and metastasis-suppressing functions, modulation of signaling pathways, transmembrane receptors and a class of miRs, which interfere with targets which do not fit into these categories. Finally, we discuss the principles of miR inhibition and reconstitution of function, prospective clinical evaluation of with miR-related agents in the context of clinical evaluation in metastasis relevant settings.

中文翻译：

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临床前体内模型中涉及大肠癌转移的microRNA和相应靶标。

大肠癌患者的高死亡人数归因于难以治疗的转移性疾病。肝是转移的首选部位，其次是肺和腹膜。为了确定新的靶标和新的干预方式，我们调查了在临床前体内模型中调控大肠癌转移的microRNA（miR）文献。我们确定了与上一个标准相对应的12个上调的miR和19个下调的miR。鉴定的miR绝大多数（n = 16）参与上皮-间质转化（EMT）的调节。其他类别的与转移相关的miR表现出抑制肿瘤和转移的功能，信号传导途径的调节，跨膜受体和一类miR，它们干扰了不适合这些类别的靶标。最后，