Multisite Tumor Sampling Reveals Extensive Heterogeneity of Tumor and Host Immune Response in Ovarian Cancer.,Cancer Genomics & Proteomics

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Multisite Tumor Sampling Reveals Extensive Heterogeneity of Tumor and Host Immune Response in Ovarian Cancer.
Cancer Genomics & Proteomics ( IF 2.5 ) Pub Date : 2020-8-30 , DOI: 10.21873/cgp.20209
Sotirios Lakis ₁ , Vassiliki Kotoula _{2,

3} , Georgia-Angeliki Koliou ₄ , Ioannis Efstratiou ₅ , Sofia Chrisafi ₂ , Alexios Papanikolaou ₆ , Pantelis Zebekakis ₇ , George Fountzilas _{2,

8,

9}

Affiliation

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece
Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Pathology, School of Health Sciences, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Section of Biostatistics, Hellenic Cooperative Oncology Group, Athens, Greece.
Department of Pathology, Papageorgiou Hospital, Thessaloniki, Greece.
First Department of Obstetrics and Gynecology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece.
First Department of Internal Medicine, AHEPA Hospital, School of Health Sciences, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Aristotle University of Thessaloniki, Thessaloniki, Greece.
German Oncology Center, Limassol, Cyprus.

Ovarian cancer (OVCA) is characterized by genomic/molecular intra-patient heterogeneity (IPH). Tissue histology and morphological features are surrogates of the underlying genomic/molecular contexture. We assessed the morphological IPH of OVCA tumor compartments and of lymphocytic infiltrates in multiple matched samples per patient.

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