Prohibitins (PHBs) are evolutionarily conserved mitochondrial integral membrane proteins, shown to regulate mitochondrial structure and function, and can be classified into PHB1 and PHB2. PHB1 and PHB2 have been shown to interact with each other, and form heterodimers in mitochondrial inner membrane. Plasmodium falciparum has orthologues of PHB1 and PHB2 in its genome, and their role is unclear. Here, by homology modelling and yeast two-hybrid analysis, we show that putative Plasmodium PHBs (Pf PHB1 and Pf PHB2) interact with each other, which suggests that they could form supercomplexes of heterodimers in Plasmodium, the functional form required for optimum mitochondrial function.


中文翻译：

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恶性疟原虫的禁止素和禁止素2在酵母中的功能研究。


抑制素（PHB）是进化上保守的线粒体整合膜蛋白，显示出调节线粒体结构和功能的功能，可以分为PHB1和PHB2。PHB1和PHB2已显示彼此相互作用，并在线粒体内膜中形成异二聚体。恶性疟原虫在其基因组中具有直向同源物PHB1和PHB2，其作用尚不清楚。在这里，通过同源性建模和酵母双杂交分析，我们发现推定的疟原虫PHB（P f PHB1和P f PHB2）彼此相互作用，这表明它们可以在疟原虫中形成异源二聚体的超复合物，这是实现最佳选择的功能形式线粒体功能。