Plastic is produced, used, and accumulated exponentially. Humans can take it through the food chain, and microplastics can be potentially toxic to humans. In this study, we analyzed the surface patterns of microplastics and their effects on humans using polyvinyl chloride (PVC) and acrylonitrile butadiene styrene (ABS). The surface analysis of these microplastics will be used as a standardized measurement method for microplastic detection and will be used as an indicator of the impact of environmental pollution caused by microplastics on humans. We have used a statistical method to analyze the shape of the milled microplastics and estimated the local curvature for each plastic type and found that PVC microplastics have a more rugged shape than the ABS microplastics. We also analyzed the toxicity of PVC and ABS microplastics. Larger PVC tended to induce the release of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α). Smaller ABS induced the release of IL-6 at high concentrations. However, larger ABS tended to induce the release of TNF-α at all concentrations. Thus, we concluded that microplastics can induce immune responses.

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微塑料的表面图案分析及其对人源细胞的影响

塑料的生产，使用和累积成倍增长。人类可以通过食物链来摄取它，而微塑料可能对人类有潜在的毒性。在这项研究中，我们使用聚氯乙烯（PVC）和丙烯腈丁二烯苯乙烯（ABS）分析了微塑料的表面图案及其对人体的影响。这些微塑料的表面分析将用作微塑料检测的标准化测量方法，并将用作微塑料对人类造成的环境污染影响的指标。我们已经使用一种统计方法来分析研磨的微塑料的形状，并估计每种塑料类型的局部曲率，并且发现PVC微塑料比ABS微塑料具有更坚固的形状。我们还分析了PVC和ABS微塑料的毒性。较大的PVC倾向于诱导白介素6（IL-6）和肿瘤坏死因子-α（TNF-α）的释放。较小的ABS可诱导高浓度IL-6的释放。但是，较大的ABS倾向于在所有浓度下诱导TNF-α的释放。因此，我们得出结论，微塑料可以诱导免疫反应。