Sequential digital dermoscopic imaging (SDDI) compares surface microscopy images of skin lesions over multiple time points. We utilized a retrospective SDDI cohort to investigate the development of dermoscopic features associated with malignancy in melanoma in situ (MIS). A total of 124 in situ melanomas were assessed from 110 Caucasian patients aged ≥18 years, with ≥2 serial images obtained between 1999 and 2017 and followed for a mean 41 months (3–142). As a positive control group, 58 invasive melanomas from 53 patients were also reviewed. Change in MIS size or number of colours correlated to time (both p < .001). The odds of MIS displaying ≥3 clues to malignancy also correlated to time (OR 5.6–52.1) (p < .05). 75% of in situ melanomas matched a dermoscopic subtype on final imaging. While a clinically significant minority of in situ melanomas were unchanged or lost dermoscopic features, lesions predominantly increased in morphological complexity over time. Longer follow‐up periods allow dermoscopic features associated with malignancy and histopathological progression to develop.

中文翻译：

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使用修正模式分析进行原位黑色素瘤的形态学演变

连续数字皮肤镜成像 (SDDI) 比较多个时间点皮肤病变的表面显微镜图像。我们利用回顾性 SDDI 队列来研究与原位黑色素瘤 (MIS) 恶性肿瘤相关的皮肤镜特征的发展。从 110 名年龄≥18 岁的白人患者中评估了总共 124 例原位黑色素瘤，在 1999 年至 2017 年期间获得了≥2 张连续图像，平均随访 41 个月 (3-142)。作为阳性对照组，还审查了来自 53 名患者的 58 例侵袭性黑色素瘤。MIS 大小或颜色数量的变化与时间相关（均p  < .001）。MIS 显示≥3 条恶性肿瘤线索的几率也与时间相关（OR 5.6-52.1）（p < .05）。75% 的原位黑色素瘤在最终成像上与皮肤镜亚型相匹配。虽然有临床意义的少数原位黑色素瘤没有改变或失去皮肤镜特征，但随着时间的推移，病变的形态复杂性主要增加。更长的随访时间允许与恶性肿瘤和组织病理学进展相关的皮肤镜特征发展。