miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.

中文翻译：

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miRNA的治疗进展：临床前和临床更新

miRNAs是一类小的内源性RNAs，是必不可少的生物药物之一，近年来已作为下一代药物进入了商业应用。已经讨论了将miRNA用作生物药物的当前情况的快照。在这项工作中，已经审查了与miRNA合作的生物制药公司以及有关miRNA治疗剂的临床前/临床试验的现状。最后，已经说明了关于吸收，分布，代谢和排泄（ADME）以及miRNA递送系统的最新更新。