With the pandemic emergence of SARS-CoV-2, the exposure of cell substrates used for manufacturing of medicines has become a possibility. Cell lines used in biomanufacturing were thus evaluated for their SARS-CoV-2 susceptibility, and the detection of SARS-CoV-2 in culture supernatants by routine adventitious virus testing of fermenter harvest tested.

中文翻译：

---

SARS-CoV-2和基于细胞的生物药品的安全系数。

随着SARS-CoV-2大流行的出现，用于制造药物的细胞基质的暴露已成为可能。因此，评估了生物制造中使用的细胞系对SARS-CoV-2的敏感性，并通过对发酵罐收获物进行常规不定病毒测试，检测了培养上清液中的SARS-CoV-2。