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Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose.
Science ( IF 41.845 ) Pub Date : 2020-10-16 , DOI: 10.1126/science.abd6176
Paul A Muller,Fanny Matheis,Marc Schneeberger,Zachary Kerner,Veronica Jové,Daniel Mucida

The gut microbiota affects tissue physiology, metabolism, and function of both the immune and nervous systems. We found that intrinsic enteric-associated neurons (iEANs) in mice are functionally adapted to the intestinal segment they occupy; ileal and colonic neurons are more responsive to microbial colonization than duodenal neurons. Specifically, a microbially responsive subset of viscerofugal CART+ neurons, enriched in the ileum and colon, modulated feeding and glucose metabolism. These CART+ neurons send axons to the prevertebral ganglia and are polysynaptically connected to the liver and pancreas. Microbiota depletion led to NLRP6- and caspase 11–dependent loss of CART+ neurons and impaired glucose regulation. Hence, iEAN subsets appear to be capable of regulating blood glucose levels independently from the central nervous system.

更新日期:2020-10-15

 

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