Lateral habenula (LHb) is a brain region acting as a hub mediating aversive response against noxious, stressful stimuli. Growing evidences indicated that LHb modulates aminergic activities to induce avoidance behavior against nociceptive stimuli. Given overlapped neural circuitry transmitting pain and itch information, it is likely that LHb have a role in processing itch information. Here, we examined whether LHb is involved in itchy response induced by histamine. We found that histamine injection enhances Fos (+) cells in posterior portion within parvocellular and central subnuclei of the medial division (LHbM) of the LHb. Moreover, chemogenetic suppression of LHbM reduced scratching behavior induced by histamine injection. These results suggest that LHb is required for processing itch information to induce histaminergic itchy response.

中文翻译：

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外侧ha足主要参与组胺引起的瘙痒感。

外侧唇（LHb）是一个大脑区域，可作为枢纽，介导对有害，压力刺激的厌恶反应。越来越多的证据表明，LHb调节胺能活性，从而诱导针对伤害性刺激的回避行为。给定重叠的神经电路传递疼痛和瘙痒信息，LHb可能在处理瘙痒信息中起作用。在这里，我们检查了LHb是否参与由组胺引起的瘙痒反应。我们发现，组胺注射增强了LHb内侧分裂（LHbM）小细胞和中央亚核后部的Fos（+）细胞。此外，LHbM的化学生成抑制降低了组胺注射液诱导的抓挠行为。这些结果表明，LHb是处理痒信息以诱导组胺能瘙痒反应所必需的。