Clinically, severe burns remain one of the most challenging issues, but an ideal treatment is yet absent. Our purpose is to compare the efficacy of stem cell therapy in a preclinical model of burn wound healing. Research reports on mesenchymal stem cells (MSCs) for burn wound healing were retrieved from 5 databases: PubMed, Embase, MEDLINE, Web of Science, and the Cochrane Library. The primary outcomes reported in this article include the un-healing rate of the wound area, the closure rate, and the wound area. Secondary outcomes included CD-31, vascular density, interleukin (IL)-10, thickness of eschar tissue, vascular endothelial growth factor (VEGF), and white blood cell count. Finally, a subgroup analysis was conducted to explore heterogeneity that potentially impacted the primary outcomes. A fixed-effects model with a 95% confidence interval (CI) was performed when no significant heterogeneity existed. Otherwise, a random-effects model was used. All data analysis was conducted by using Engauge Digitizer 10.8 and R software. Twenty eligible articles were finally included in the analysis. Stem cell therapy greatly improved the closure rate (2.00, 95% CI 0.52 to 3.48, p = 0.008) and compromised the wound area (− 2.36; 95% CI − 4.90 to 0.18; p = 0.069) rather than the un-healing rate of the wound area (− 11.10, 95% CI − 32.97 to 10.78, p = 0.320). Though p was 0.069, there was a trend toward shrinkage of the burn wound area after stem cell therapy. Vascular density (4.69; 95% CI 0.06 to 9.31; p = 0.047) and thickness of eschar tissue (6.56, 95% CI 1.15 to 11.98, p = 0.017) were also discovered to be significantly improved in the burn site of stem cell-treated animals. Moreover, we observed that animals in the stem cell group had an increased white blood cell count (0.84, 95% CI 0.01 to 1.66, p = 0.047) 5 days post treatment. Other indicators, such as VEGF (p = 0.381), CD-31 (p = 0.335) and IL-10 (p = 0.567), were not significantly impacted. Despite limited data from preclinical trials, this meta-analysis suggests that stem cell therapy is curative in decreasing the burn wound area and provides some insights into future clinical studies of stem cell therapy for burns.

中文翻译：

---

间充质干细胞移植治疗动物烧伤的功效评估：系统综述。

在临床上，严重烧伤仍然是最具挑战性的问题之一，但尚缺乏理想的治疗方法。我们的目的是在烧伤创面的临床前模型中比较干细胞疗法的功效。从5个数据库中检索了用于烧伤伤口愈合的间充质干细胞（MSC）的研究报告：PubMed，Embase，MEDLINE，Web of Science和Cochrane库。本文报道的主要结果包括伤口愈合率，闭合率和伤口愈合率。次要结果包括CD-31，血管密度，白介素（IL）-10，焦char厚度，血管内皮生长因子（VEGF）和白细胞计数。最后，进行了亚组分析以探讨可能影响主要结果的异质性。当不存在显着的异质性时，执行具有95％置信区间（CI）的固定效应模型。否则，使用随机效应模型。所有数据分析均使用Engauge Digitizer 10.8和R软件进行。最终有20篇符合条件的文章被纳入分析。干细胞疗法极大地改善了闭合率（2.00，95％CI 0.52至3.48，p = 0.008）并损害了伤口区域（− 2.36; 95％CI − 4.90至0.18; p = 0.069）而不是治愈率伤口面积的平均值（− 11.10，95％CI − 32.97至10.78，p = 0.320）。尽管p为0.069，但是在干细胞治疗后有烧伤创面缩小的趋势。骨组织的血管密度（4.69; 95％CI 0.06至9.31; p = 0.047）和厚度（6.56，95％CI 1.15至11.98，p = 0）。017）还发现在经干细胞处理的动物的烧伤部位明显改善。此外，我们观察到，治疗后5天，干细胞组中的动物白细胞计数增加（0.84，95％CI 0.01至1.66，p = 0.047）。VEGF（p = 0.381），CD-31（p = 0.335）和IL-10（p = 0.567）等其他指标并未受到明显影响。尽管临床前试验的数据有限，但这项荟萃分析表明，干细胞疗法可有效减少烧伤创面面积，并为今后烧伤干细胞疗法的临床研究提供一些见识。335）和IL-10（p = 0.567）没有受到明显影响。尽管临床前试验的数据有限，但这项荟萃分析表明，干细胞疗法可有效减少烧伤创面面积，并为今后烧伤干细胞疗法的临床研究提供一些见识。335）和IL-10（p = 0.567）没有受到明显影响。尽管临床前试验的数据有限，但这项荟萃分析表明，干细胞疗法可有效减少烧伤创面面积，并为今后烧伤干细胞疗法的临床研究提供一些见识。