This study reports the synthesis of the room temperature ionic liquid 1-propyloxy-3-ethoxyimidazolium bis(trifluoromethane)sulfonamide for the extraction of bergapten and bergamottin from hydroalcoholic cosmetic samples by means of dispersive liquid–liquid microextraction. Molecular structures of the final ionic liquid as well as intermediate products were confirmed by nuclear magnetic resonance spectroscopy. Analyses were performed with high performance liquid chromatography with subsequent diode array and fluorescence detection. The extraction procedure was optimized with the design of the experiment using a three level Box–Behnken approach. Applying the synthesized room temperature ionic liquid as extraction medium, the optimized workflow demonstrated high recoveries illustrating powerful isolation properties for furanocoumarins, which are comparable or even better than using typical extraction solvents. Moreover, the workflow was validated regarding instrumental limits, linearity, accuracy, repeatability and stability of analytes according to international guidelines. To test its applicability on a more complex matrix, hydroalcoholic cosmetic samples were analyzed. Despite highly complex matrices, accurate and precise quantification in the range of 0.04–1.25 μg mL⁻¹ was achieved in spiked and unspiked samples, with bias <10% and RSD < 12%.

中文翻译：

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基于离子液体的新型分散液-液微萃取技术，用于提取水醇化妆品配方中的佛手柑和佛手柑。

这项研究报告了室温离子液体1-丙氧基-3-乙氧基咪唑鎓双（三氟甲烷）磺酰胺的合成，用于通过分散液-液微萃取从水醇化妆品样品中提取佛手柑和佛手柑。最终的离子液体以及中间产物的分子结构通过核磁共振波谱证实。用高效液相色谱法进行分析，随后进行二极管阵列和荧光检测。使用三级Box-Behnken方法通过实验设计优化了提取程序。采用合成的室温离子液体作为萃取介质，优化的工作流程显示出高回收率，说明呋喃香豆素具有强大的分离特性，与使用典型的萃取溶剂相当甚至更好。此外，根据国际准则对工作流程进行了仪器极限，线性，准确性，可重复性和稳定性的验证。为了测试其在更复杂的基质上的适用性，分析了水醇化妆品样品。尽管基质非常复杂，但仍可在0.04–1.25μgmL范围内进行准确而精确的定量在加标和未加标样品中均达到^-1，偏差<10％，RSD <12％。