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Scleromyxoedema, blistering lesions and progressive sensorimotor neuropathy in Waldenström’s macroglobulinaemia
Practical Neurology Pub Date : 2020-08-27 , DOI: 10.1136/practneurol-2020-002577 Poornima Jayadev Menon 1 , Michael D Alexander 2, 3 , Lisa Costelloe 4 , Julie MacMahon 5 , Anne-Marie Tobin 5 , Ronan Desmond 6 , Sinéad M Murphy 7
Practical Neurology Pub Date : 2020-08-27 , DOI: 10.1136/practneurol-2020-002577 Poornima Jayadev Menon 1 , Michael D Alexander 2, 3 , Lisa Costelloe 4 , Julie MacMahon 5 , Anne-Marie Tobin 5 , Ronan Desmond 6 , Sinéad M Murphy 7
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A 62-year-old man reported tingling and numbness in his hands over 8 months that had progressed to his wrists, and with hand weakness. Two years previously he had developed thickening of the skin on his face and blistering skin lesions on his hands. He also reported erectile dysfunction. On examination, his facial skin was visibly thickened (figure 1). There was an ulcer overlying the second right proximal inter-phalangeal joint with the tendon exposed (figure 2) and multiple similar lesions on the hands. There was wasting of intrinsic hand muscles and extensor digitorum brevis. He had significant distal weakness in upper and lower limbs. Supinator and ankle reflexes were absent. Sensory examination showed absent pinprick and vibration sensation distally. Figure 1 Thickening of the facial skin. Figure 2 Ulcers overlying the proximal interphalangeal joint of the second digit and the medial aspect of the third digit …
中文翻译:
Waldenström 巨球蛋白血症的硬化性粘液水肿、水疱性病变和进行性感觉运动神经病
一名 62 岁男性报告称,在 8 个月内,双手出现刺痛和麻木,并进展至手腕,并伴有手部无力。两年前,他脸上的皮肤变厚,手上出现起泡的皮肤病变。他还报告了勃起功能障碍。检查时,他的面部皮肤明显增厚(图 1)。有一个溃疡覆盖在右侧第二个近端指间关节上,肌腱暴露(图 2)和手上多个类似的病变。手部内在肌肉和趾短伸肌萎缩。他有明显的上肢和下肢远端无力。旋后反射和踝反射消失。感觉检查显示远端无针刺感和振动感。图 1 面部皮肤增厚。
更新日期:2020-08-27
中文翻译:
Waldenström 巨球蛋白血症的硬化性粘液水肿、水疱性病变和进行性感觉运动神经病
一名 62 岁男性报告称,在 8 个月内,双手出现刺痛和麻木,并进展至手腕,并伴有手部无力。两年前,他脸上的皮肤变厚,手上出现起泡的皮肤病变。他还报告了勃起功能障碍。检查时,他的面部皮肤明显增厚(图 1)。有一个溃疡覆盖在右侧第二个近端指间关节上,肌腱暴露(图 2)和手上多个类似的病变。手部内在肌肉和趾短伸肌萎缩。他有明显的上肢和下肢远端无力。旋后反射和踝反射消失。感觉检查显示远端无针刺感和振动感。图 1 面部皮肤增厚。