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Secoiridoids and Iridoids from Morinda asteroscepa.
Journal of Natural Products ( IF 5.1 ) Pub Date : 2020-08-27 , DOI: 10.1021/acs.jnatprod.0c00447
Linda Zandi 1 , Marco Makungu 1, 2 , Joan J E Munissi 2 , Sandra Duffy 3 , Rakesh Puttreddy 4 , Daniel von der Heiden 5 , Kari Rissanen 4 , Vicky M Avery 3 , Stephen S Nyandoro 1, 2 , Máté Erdélyi 1, 5
Affiliation  

The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (47) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 13 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7).

中文翻译:

来自海巴戟的 Secoiridoids 和 Iridoids。

从叶和茎皮甲醇提取物中分离出新的 2,3-secoiridoids morisecoiridoic酸 A ( 1 ) 和 B ( 2 )、新的环烯醚萜 8-乙酰氧基表山基内酯 ( 3 ) 和另外四种已知的环烯醚萜 ( 47 )巴戟天使用色谱方法。修正山子内酯( 4 )的结构。纯化的代谢物使用 NMR 光谱和质谱技术进行鉴定,1的绝对构型已通过单晶 X 射线衍射分析确定。将粗叶提取物(10微克/ mL)和化合物1 - 35 (10 μM) 对氯喹敏感的疟原虫恶性疟原虫(3D7)显示出温和的抗疟原虫活性。
更新日期:2020-09-25
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