The present study aims to investigate intrinsic abnormalities of brain and the effect of antiepileptic treatment on brain activity in Benign childhood epilepsy with centrotemporal spikes (BECTS). Twenty-six drug-naïve patients (DNP) and 22 drug-receiving patients (DRP) with BECTS were collected in this study. Static amplitude of low frequency fluctuation (sALFF) and dynamic ALFF (dALFF) were applied to resting-state fMRI data. Functional connectivity (FC) analysis was further performed for affected regions identified by static and dynamic analysis. One-way analysis of variance and post hoc statistical analyses were performed for between-group differences. Abnormal sALFF and dALFF values were correlated with clinical features of patients. Compared with healthy controls (HC), DNP group demonstrated alterations of sALFF and/or dALFF in medial prefrontal cortex (MPFC), supplementary motor areas (SMA), cerebellum, hippocampus, pallidum and cingulate cortex, in which the values were close to normal in DRP. Notably, sALFF and dALFF showed specific sensitivity in detecting abnormalities in basal ganglia and cerebellum. Additionally, DRP showed additional changes in precuneus, inferior temporal gyrus, superior frontal gyrus and occipital visual cortex. Compared with HC, the DNP showed increased FC in default network and motion-related networks, and the DRP showed decreased FC in default network. The MPFC, hippocampus, SMA, basal ganglia and cerebellum are indicated to be intrinsically affected regions and effective therapeutic targets. And the FC profiles of default and motion-related networks might be potential core indicators for clinical treatment. This study revealed potential neuromodulatory targets and helped understand pathomechanism of BECTS. Static and dynamic analyses should be combined to investigate neuropsychiatric disorders.

中文翻译：

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改变初治和接受药物治疗的良性儿童癫痫的静态和动态自发神经活动

本研究旨在调查大脑的内在异常以及抗癫痫治疗对伴有中心颞部棘波的良性儿童癫痫 (BECTS) 大脑活动的影响。本研究收集了 26 名未接受药物治疗的患者 (DNP) 和 22 名接受药物治疗的 BECTS 患者 (DRP)。低频波动的静态幅度 (sALFF) 和动态 ALFF (dALFF) 被应用于静息状态 fMRI 数据。对通过静态和动态分析确定的受影响区域进一步进行了功能连接 (FC) 分析。对组间差异进行单向方差分析和事后统计分析。sALFF 和 dALFF 值异常与患者的临床特征相关。与健康对照（HC）相比，DNP组显示内侧前额叶皮层（MPFC）、辅助运动区（SMA）、小脑、海马、苍白球和扣带回皮层sALFF和/或dALFF的改变，其中DRP值接近正常。值得注意的是，sALFF 和 dALFF 在检测基底神经节和小脑异常方面表现出特殊的敏感性。此外，DRP 显示楔前叶、颞下回、额上回和枕叶视觉皮层的额外变化。与HC相比，DNP在默认网络和运动相关网络中显示出增加的FC，而DRP在默认网络中显示出减少的FC。MPFC、海马、SMA、基底神经节和小脑被认为是内在受影响的区域和有效的治疗靶点。默认和运动相关网络的 FC 配置文件可能是临床治疗的潜在核心指标。这项研究揭示了潜在的神经调节目标，并有助于了解 BECTS 的病理机制。应结合静态和动态分析来调查神经精神疾病。