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Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits.
Communications Biology ( IF 5.9 ) Pub Date : 2020-08-28 , DOI: 10.1038/s42003-020-01199-3
Yuzhe Wang 1, 2 , Xuemin Cao 1 , Chenglong Luo 3 , Zheya Sheng 1, 4 , Chunyuan Zhang 1, 5 , Cheng Bian 1 , Chungang Feng 1 , Jinxiu Li 1 , Fei Gao 1, 2, 5 , Yiqiang Zhao 1, 5 , Ziqin Jiang 1 , Hao Qu 3 , Dingming Shu 3 , Örjan Carlborg 6 , Xiaoxiang Hu 1 , Ning Li 1
Affiliation  

In depth studies of quantitative trait loci (QTL) can provide insights to the genetic architectures of complex traits. A major effect QTL at the distal end of chicken chromosome 1 has been associated with growth traits in multiple populations. This locus was fine-mapped in a fifteen-generation chicken advanced intercross population including 1119 birds and explored in further detail using 222 sequenced genomes from 10 high/low body weight chicken stocks. We detected this QTL that, in total, contributed 14.4% of the genetic variance for growth. Further, nine mosaic precise intervals (Kb level) which contain ancestral regulatory variants were fine-mapped and we chose one of them to demonstrate the key regulatory role in the duodenum. This is the first study to break down the detail genetic architectures for the well-known QTL in chicken and provides a good example of the fine-mapping of various of quantitative traits in any species.



中文翻译:

含有调节突变的多个祖先单倍型累积导致影响鸡生长性状的 QTL。

对数量性状基因座 (QTL) 的深入研究可以为复杂性状的遗传结构提供见解。鸡 1 号染色体末端的一个主要效应 QTL 与多个种群的生长性状有关。该基因座在包括 1119 只鸟的 15 代鸡高级交叉种群中进行了精细定位,并使用来自 10 个高/低体重鸡群的 222 个测序基因组进行了进一步详细探索。我们检测到这个 QTL,它总共贡献了 14.4% 的生长遗传变异。此外,包含祖先调节变体的九个马赛克精确间隔(Kb 水平)被精细定位,我们选择其中之一来证明十二指肠中的关键调节作用。

更新日期:2020-08-28
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