Dedicated to Andy Phillips for his mentorship and support.

Abstract

Carolacton, a macrocyclic natural product with impressive anti-biofilm biological activity, has been a focus in multiple research groups for the past decade. Chemists and biologists, alike, have been interested in uncovering the mechanism of action and have made great strides towards this goal. Carolacton causes cellular defects in Streptococcus mutans biofilm, which leads to decreases in cellular viability. As biological targets have been uncovered, synthetic chemists have devised synthetic routes that have helped uncover the important chemical functionalities that lead to biological activity. Herein, we discuss our synthetic collaboration that galvanized an entire research program around the natural product carolacton.

中文翻译：

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天然产物全合成方面的合作：Carolacton –十年的发现

致力于Andy Phillips的指导和支持。

抽象

Carolacton是一种具有令人印象深刻的抗生物膜生物活性的大环天然产物，在过去十年中一直是多个研究小组的关注重点。化学家和生物学家都对发现作用机理感兴趣，并朝着这一目标迈出了一大步。Carolacton导致变形链球菌生物膜中的细胞缺陷，从而导致细胞活力降低。由于已经发现了生物学目标，合成化学家已经设计出合成路线，这些路线有助于发现导致生物学活性的重要化学功能。在这里，我们讨论了我们的合成合作，该合作激发了围绕天然产物carolacton的整个研究计划。