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Instability of natural selection at candidate barrier loci underlying speciation in wood ants.
Molecular Ecology ( IF 4.9 ) Pub Date : 2020-08-27 , DOI: 10.1111/mec.15606 Jonna Kulmuni 1, 2 , Pierre Nouhaud 1 , Lucy Pluckrose 1 , Ina Satokangas 1 , Kishor Dhaygude 1 , Roger K Butlin 3, 4
Molecular Ecology ( IF 4.9 ) Pub Date : 2020-08-27 , DOI: 10.1111/mec.15606 Jonna Kulmuni 1, 2 , Pierre Nouhaud 1 , Lucy Pluckrose 1 , Ina Satokangas 1 , Kishor Dhaygude 1 , Roger K Butlin 3, 4
Affiliation
Speciation underlies the generation of novel biodiversity. Yet, there is much to learn about how natural selection shapes genomes during speciation. Selection is assumed to act against gene flow at barrier loci, promoting reproductive isolation. However, evidence for gene flow and selection is often indirect and we know very little about the temporal stability of barrier loci. Here we utilize haplodiploidy to identify candidate male barrier loci in hybrids between two wood ant species. As ant males are haploid, they are expected to reveal recessive barrier loci, which can be masked in diploid females if heterozygous. We then test for barrier stability in a sample collected 10 years later and use survival analysis to provide a direct measure of natural selection acting on candidate male barrier loci. We find multiple candidate male barrier loci scattered throughout the genome. Surprisingly, a proportion of them are not stable after 10 years, natural selection apparently switching from acting against to favouring introgression in the later sample. Instability of the barrier effect and natural selection for introgressed alleles could be due to environment‐dependent selection, emphasizing the need to consider temporal variation in the strength of natural selection and the stability of the barrier effect at putative barrier loci in future speciation work.
中文翻译:
在木蚂蚁物种形成的潜在障碍位点上自然选择的不稳定性。
物种形成是新型生物多样性的基础。但是,关于自然选择如何在物种形成过程中塑造基因组的知识还有很多。假定选择对屏障位点处的基因流不利,从而促进生殖分离。但是,基因流动和选择的证据通常是间接的,我们对屏障基因座的时间稳定性了解甚少。在这里,我们利用单倍体来识别两种木蚁物种之间的杂交中的候选雄性屏障位点。由于蚂蚁雄性是单倍体,因此它们有望显示出隐性屏障位点,如果杂合的话,它们可以在二倍体雌性中被掩盖。然后,我们在10年后收集的样本中测试屏障稳定性,并使用生存分析提供直接测量作用于候选雄性屏障位点的自然选择的方法。我们发现多个候选男性障碍位点散布在整个基因组中。令人惊讶的是,其中的一部分在10年后仍不稳定,自然选择显然在后来的样本中从反抗转变为有利于渗入。渗入等位基因的屏障效应和自然选择的不稳定性可能归因于环境依赖性选择,强调在未来的物种形成工作中需要考虑自然选择强度的时空变化和推定屏障位点的屏障效应的稳定性。
更新日期:2020-10-13
中文翻译:
在木蚂蚁物种形成的潜在障碍位点上自然选择的不稳定性。
物种形成是新型生物多样性的基础。但是,关于自然选择如何在物种形成过程中塑造基因组的知识还有很多。假定选择对屏障位点处的基因流不利,从而促进生殖分离。但是,基因流动和选择的证据通常是间接的,我们对屏障基因座的时间稳定性了解甚少。在这里,我们利用单倍体来识别两种木蚁物种之间的杂交中的候选雄性屏障位点。由于蚂蚁雄性是单倍体,因此它们有望显示出隐性屏障位点,如果杂合的话,它们可以在二倍体雌性中被掩盖。然后,我们在10年后收集的样本中测试屏障稳定性,并使用生存分析提供直接测量作用于候选雄性屏障位点的自然选择的方法。我们发现多个候选男性障碍位点散布在整个基因组中。令人惊讶的是,其中的一部分在10年后仍不稳定,自然选择显然在后来的样本中从反抗转变为有利于渗入。渗入等位基因的屏障效应和自然选择的不稳定性可能归因于环境依赖性选择,强调在未来的物种形成工作中需要考虑自然选择强度的时空变化和推定屏障位点的屏障效应的稳定性。