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Regen med therapeutic opportunities for fighting COVID-19.
STEM CELLS Translational Medicine ( IF 6 ) Pub Date : 2020-08-27 , DOI: 10.1002/sctm.20-0245
Anthony Atala 1 , Alicia Henn 2 , Martha Lundberg 3 , Taby Ahsan 4 , Jordan Greenberg 5 , Jeff Krukin 6 , Steven Lynum 7 , Cat Lutz 8 , Kyle Cetrulo 9 , Mohammad Albanna 10 , Taciana Pereira 11 , Shannon Eaker 12 , Joshua Hunsberger 13
Affiliation  

This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID‐19. This article addresses why SARS‐CoV‐2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeutic opportunities to battle COVID‐19. We describe animal models that depict the mechanism of action for COVID‐19 and that may help identify new treatments. Additionally, organoid platforms that can recapitulate some of the physiological properties of human organ systems, such as the lungs and the heart, are discussed as potential platforms that may prove useful in rapidly screening new drugs and identifying at‐risk patients. This article critically evaluates some of the promising regenerative medicine‐based therapies for treating COVID‐19 and presents some of the collective technologies and resources that the scientific community currently has available to confront this pandemic.

中文翻译:

为抗击COVID-19提供医学治疗机会。

再生医学制造协会工作组的这一观点强调了对抗COVID-19的再生医学治疗机会。本文讨论了SARS‐CoV‐2与其他病毒为何如此不同的原因,以及再生医学如何准备提供新的治疗机会来对抗COVID‐19。我们描述的动物模型描述了COVID-19的作用机制,可能有助于确定新的治疗方法。此外,讨论了可以概括人体器官系统(如肺和心脏)某些生理特性的类器官平台,这是可能被证明可用于快速筛选新药和识别高危患者的潜在平台。
更新日期:2020-08-27
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