BACKGROUND The role of subthreshold depression (subD) in Parkinson's Disease (PD) is not clear. The present study aimed to compare the quality of life (QoL) in PD patients with subD vs patients with no depressive disorder (nonD). Factors related to subD were identified. MATERIAL AND METHODS PD patients and controls recruited from the COPPADIS cohort were included. SubD was defined as Judd criteria. The 39-item Parkinson's disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8) were used to assess QoL. RESULTS The frequency of depressive symptoms was higher in PD patients (n = 694) than in controls (n = 207) (p < 0.0001): major depression, 16.1% vs 7.8%; minor depression, 16.7% vs 7.3%; subD, 17.4% vs 5.8%. Both health-related QoL (PDQ-39; 18.1 ± 12.8 vs 11.6 ± 10; p < 0.0001) and global QoL (EUROHIS-QOL8; 3.7 ± 0.5 vs 4 ± 0.5; p < 0.0001) were significantly worse in subD (n = 120) than nonD (n = 348) PD patients. Non-motor Symptoms Scale (NMSS) total score was higher in subD patients (45.9 ± 32 vs 29.1 ± 25.8;p < 0.0001). Non-motor symptoms burden (NMSS;OR = 1.019;95%CI 1.011-1.028; p < 0.0001), neuropsychiatric symptoms (NPI; OR = 1.091; 95%CI 1.045-1.139; p < 0.0001), impulse control behaviors (QUIP-RS; OR = 1.035; 95%CI 1.007-1063; p = 0.013), quality of sleep (PDSS; OR = 0.991; 95%CI 0.983-0.999; p = 0.042), and fatigue (VAFS-physical; OR = 1.185; 95%CI 1.086-1.293; p < 0.0001; VAFS-mental; OR = 1.164; 95%CI 1.058-1.280; p = 0.0001) were related to subD after adjustment to age, disease duration, daily equivalent levodopa dose, motor status (UPDRS-III), and living alone. CONCLUSIONS SubD is a frequent problem in patients with PD and is more prevalent in these patients than in controls. QoL is worse and non-motor symptoms burden is greater in subD PD patients.

中文翻译：

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帕金森病阈下抑郁症患者的生活质量和非运动症状

背景阈下抑制（subD）在帕金森病（PD）中的作用尚不清楚。本研究旨在比较患有 subD 的 PD 患者与没有抑郁症 (nonD) 的患者的生活质量 (QoL)。确定了与 subD 相关的因素。材料和方法 包括从 COPPADIS 队列招募的 PD 患者和对照。SubD 被定义为贾德标准。使用 39 项帕金森病问卷 (PDQ-39) 和 EUROHIS-QOL 8 项指数 (EUROHIS-QOL8) 评估 QoL。结果 PD 患者（n = 694）的抑郁症状频率高于对照组（n = 207）（p < 0.0001）：重度抑郁症，16.1% vs 7.8%；轻度抑郁症，16.7% 对 7.3%；subD，17.4% 对 5.8%。与健康相关的 QoL (PDQ-39; 18.1 ± 12.8 vs 11.6 ± 10; p < 0.0001) 和全球 QoL (EUROHIS-QOL8; 3. 7 ± 0.5 对 4 ± 0.5；p < 0.0001) 在 subD (n = 120) 中比非 D (n = 348) PD 患者显着更差。subD 患者的非运动症状量表 (NMSS) 总分较高（45.9 ± 32 vs 29.1 ± 25.8；p < 0.0001）。非运动症状负担（NMSS；OR = 1.019；95%CI 1.011-1.028；p < 0.0001）、神经精神症状（NPI；OR = 1.091；95%CI 1.045-1.139；p < 0.0001）（QUIP 控制行为） -RS；OR = 1.035；95%CI 1.007-1063；p = 0.013）、睡眠质量（PDSS；OR = 0.991；95%CI 0.983-0.999；p = 0.042）和疲劳（VAFS-身体；OR = 1.185；95%CI 1.086-1.293；p < 0.0001；VAFS-精神；OR = 1.164；95%CI 1.058-1.280；p = 0.0001）在调整到年龄、疾病持续时间、每日等效运动左旋多巴后与 subD 相关状态 (UPDRS-III) 和独居。结论 SubD 是 PD 患者的常见问题，并且在这些患者中比在对照组中更为普遍。subD PD 患者的 QoL 更差，非运动症状负担更大。