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Evaluating the mechanical response of novel synthetic femurs for representing osteoporotic bone.
Journal of Biomechanics ( IF 2.4 ) Pub Date : 2020-08-28 , DOI: 10.1016/j.jbiomech.2020.110018
Cooper Gluek 1 , Radovan Zdero 2 , Cheryl E Quenneville 3
Affiliation  

Osteoporosis is a disease prevalent in older adults, characterized by high porosity in bone and subsequent decrease in fracture resistance. This demographic is also the population that most frequently receives devices such as hip implants. However, high porosity complicates surgery and reduces the fixation and effectiveness of orthopaedic devices, which are typically designed using cadaveric specimens from the general population. Synthetic bones are also used in the design of such devices but need to represent the properties of the patient population. Thus, the mechanical response of two iterations of novel synthetic femurs were evaluated for their ability to represent osteoporotic cadaveric specimens and were tested and compared against cadaveric specimens across four loading modes. The first iteration had reduced density and wall thickness compared to standard models and was typically too rigid or too stiff to be a feasible alternative to cadaveric specimens. The second iteration, with similarly reduced wall thickness and further reduced density, was quite representative, with no statistical differences identified against the cadaveric specimens in any loading mode, except in screw pullout. Such a model can provide a foundation for the development of orthopaedic devices better suited to osteoporotic bone, potentially improving surgical outcomes, reducing medical expense, and improving quality of life for patients.



中文翻译:

评价新型合成股骨代表骨质疏松骨的机械反应。

骨质疏松症是老年人中普遍存在的一种疾病,其特征是骨骼中的高孔隙度和随后的抗骨折性降低。这个人口也是最经常接受诸如髋关节植入物的设备的人群。但是,高孔隙率会使手术复杂化,并且会降低骨科器械的固定性和有效性,而骨科器械通常是使用普通人群的尸体标本设计的。合成骨骼也用于此类设备的设计中,但需要代表患者群体的特性。因此,评估了两种新型合成股骨的机械响应代表骨质疏松尸体标本的能力,并在四种加载模式下对尸体标本进行了测试和比较。与标准模型相比,第一次迭代降低了密度和壁厚,并且通常过于僵硬或太僵硬,无法替代尸体标本。第二次迭代具有类似的壁厚减小和密度进一步减小的特性,非常具有代表性,在任何加载模式下,除螺钉拔出方式外,均未发现与尸体标本的统计差异。这样的模型可以为开发更适合骨质疏松骨的骨科器械提供基础,从而有可能改善手术效果,降低医疗费用并改善患者的生活质量。具有很强的代表性,除螺丝拔出外,在任何加载模式下对尸体标本均无统计学差异。这种模型可以为开发更适合骨质疏松骨的骨科器械提供基础,从而有可能改善手术效果,降低医疗费用并改善患者的生活质量。具有很强的代表性,除螺丝拔出外,在任何加载模式下对尸体标本均无统计学差异。这种模型可以为开发更适合骨质疏松骨的骨科器械提供基础,从而有可能改善手术效果,降低医疗费用并改善患者的生活质量。

更新日期:2020-09-03
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