Abstract

In this article, a one-pot three-component synthesis of 3-aminoisoxazolmethylnaphthol derivatives has been developed using Fe₃O₄–NHPhSO₃H as a recyclable heterogeneous nanocatalyst using available 3-aminoisoazoles, aldehyde derivatives and 2-naphthol under solvent-free conditions. This environmentally friendly methodology with excellent green chemistry credentials, such as using the low loading of reusable, nontoxic, easy- to-handle catalyst, shorter reaction time without any byproduct, avoidance of hazardous organic solvents and easy workup (the catalyst can be easily separated from the reaction mixture by an external magnet), can be used in a wide range of applications.

Graphic Abstract

A one-pot three-component synthesis of 3-aminoisoxazolmethylnaphthol derivatives has been developed via Fe₃O₄–NHPhSO₃H as a recyclable heterogeneous nanocatalyst by available 3-aminoisoazoles, aldehyde derivatives and 2-naphthol in solvent-free conditions. This green process with main aspects such as operational simplicity, good-to-excellent yields, low cost, easy handling, being eco-friendly and reusability of the catalyst, absence of any tedious workup or purification and avoidance of hazardous or toxic reagents/catalysts/solvents opens an effective and convenient way to naphthalen-2-ol-functionalized isoxazole systems, which are promising compounds for different biomedical applications.

中文翻译：

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MNPs–PhSO 3 H：无溶剂条件下促进绿色合成3-氨基异恶唑甲基萘的可持续，可循环利用和环境友好的催化剂

摘要

在本文中，使用Fe ₃ O ₄ -NHPhSO ₃ H作为可回收的非均相纳米催化剂，使用无溶剂的3-氨基异唑，醛衍生物和2-萘酚，开发了一种一锅三组分合成3-氨基异恶唑甲基萘酚衍生物。条件。这种环保的方法论具有出色的绿色化学认证，例如使用低负荷的可重复使用，无毒，易于处理的催化剂，较短的反应时间而没有任何副产物，避免了有害的有机溶剂并且易于后处理（催化剂可以轻松分离（通过外部磁体从反应混合物中分离得到），可以广泛地应用。

图形摘要

已通过Fe ₃ O ₄ -NHPhSO ₃ H在无溶剂条件下通过可用的3-氨基异唑，醛衍生物和2-萘酚开发了可回收的多相纳米催化剂，通过一锅法三组分合成3-氨基异恶唑甲基萘酚衍生物。这种绿色工艺的主要方面包括操作简便，产率高至优异，成本低，易于处理，对环境友好且催化剂可重复使用，无需进行繁琐的后处理或纯化以及避免使用危险或有毒的试剂/催化剂/ solvents为萘-2-醇官能化的异恶唑系统提供了一种有效而便捷的方法，这对于不同的生物医学应用而言都是很有希望的化合物。