Advanced glycation end products (AGE) are a marker of various diseases including diabetes, in which they participate to vascular damages such as retinopathy, nephropathy and coronaropathy. Besides those vascular complications, AGE are involved in altered metabolism in many tissues, including adipose tissue (AT) where they contribute to reduced glucose uptake and attenuation of insulin sensitivity. AGE are known to contribute to type 1 diabetes (T1D) through promotion of interleukin (IL)-17 secreting T helper (Th17) cells.

中文翻译：

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糖化白蛋白参与脂肪干细胞介导的分泌T辅助细胞活化的白介素17。

晚期糖基化终末产物（AGE）是包括糖尿病在内的多种疾病的标志物，其中它们参与血管损伤，例如视网膜病变，肾病和冠状动脉病变。除那些血管并发症外，AGE还参与许多组织（包括脂肪组织（AT））的新陈代谢改变，在这些组织中，AGE有助于减少葡萄糖摄取并降低胰岛素敏感性。已知AGE通过促进分泌白介素（IL）-17的T辅助细胞（Th17）促成1型糖尿病（T1D）。