Bone marrow mesenchymal stem cells (BMSCs) are capable of shifting the microglia/macrophages phenotype from M1 to M2, contributing to BMSCs-induced brain repair. However, the regulatory mechanism of BMSCs on microglia/macrophages after ischemic stroke is unclear. Recent evidence suggests that mesencephalic astrocyte-derived neurotrophic factor (MANF) and platelet-derived growth factor-AA (PDGF-AA)/MANF signaling regulate M1/M2 macrophage polarization.

中文翻译：

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骨髓间充质干细胞通过PDGF-AA / MANF信号传导诱导M2小胶质细胞极化。

骨髓间充质干细胞（BMSC）能够将小胶质细胞/巨噬细胞表型从M1转变为M2，从而有助于BMSCs诱导的脑修复。然而，尚不清楚缺血性卒中后骨髓间充质干细胞对小胶质细胞/巨噬细胞的调控机制。最近的证据表明，中脑星形胶质细胞源性神经营养因子（MANF）和血小板源性生长因子-AA（PDGF-AA）/ MANF信号调节M1 / M2巨噬细胞极化。