Herein, we present a copper-mediated decarboxylative sulfonylation of arylacetic acids with sodium sulfinates that provides viable access to sulfone compounds. This protocol features readily available feedstocks, simple operations, high regioselectivities, and moderate to good yields. The newly obtained products could be converted to other useful compounds. Importantly, the products and their derivatives exhibited potent antitumor activities in vitro, which were tested by MTT assay.

中文翻译：

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铜介导的丙烯酸与亚磺酸钠的脱羧磺酰化反应。

在这里，我们介绍了铜磺酸与亚磺酸钠介导的芳基丙烯酸的脱羧磺酰化，提供了通向砜类化合物的可行途径。该方案的特点是易于获得的原料，操作简单，区域选择性高以及中等至良好的收率。新获得的产物可以转化为其他有用的化合物。重要的是，产物和它们的衍生物在体外表现出有效的抗肿瘤活性，这通过MTT测定法进行了测试。