Noncovalent interactions are ubiquitous in nature and are responsible for the precision control in enzyme catalysis via the cooperation of multiple active sites. Inspired by this principle, noncovalent interaction-assisted transition metal catalysis has emerged recently as a powerful tool and has attracted intense interest. However, it is still highly desirable to develop efficient and operationally convenient ligands along this line with new structural motifs. Based on the specific nature of hydrogen bonding and ion pairing interactions, we developed a series of noncovalent interaction-assisted chiral ferrocenyl phosphine ligands, including Zhaophos, Wudaphos, and miscellaneous SPO-Wudaphos. Due to the assistance of noncovalent interactions, this catalytic mode is capable of achieving transition metal catalyzed asymmetric hydrogenation and other transformations with remarkable improvement of reactivity and selectivity. In some specific challenging cases, this probably represents one of the most productive methods. Moreover, these ligands are easily prepared, air stable, and highly tunable, meeting the requirements of industrial application.

中文翻译：

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非共价相互作用辅助的二茂铁基膦配体在不对称催化中的作用。

非共价相互作用本质上是普遍存在的，并且通过多个活性位点的协作来负责酶催化中的精确控制。受此原理的启发，非共价相互作用辅助的过渡金属催化最近已成为一种强大的工具，并引起了人们的浓厚兴趣。然而，仍然非常需要沿着这条线开发具有新的结构基序的有效和操作上方便的配体。基于氢键和离子配对相互作用的特殊性质，我们开发了一系列非共价相互作用辅助的手性二茂铁基膦配体，包括昭福斯，乌达磷和其他SPO-乌达磷。由于非共价相互作用的帮助，该催化模式能够实现过渡金属催化的不对称氢化和其他转化，同时显着提高反应性和选择性。在某些特定的挑战性情况下，这可能代表了最有效的方法之一。而且，这些配体易于制备，空气稳定且高度可调，满足工业应用的要求。