Tetrazoles are an important class of nitrogen-containing heterocycles with a broad spectrum of applications in medicinal chemistry. Recent literature studies clearly showed that tetrazoles have a broad spectrum of biological and pharmacological activities such as antiallergic, antiinflammatory, antiulcer, antibiotic, antihypertensive, antineoplastic, antiviral and receptor modulator activities. Magnetic recoverable nanocatalysts can be readily separated from reaction medium by using an external magnet, without the need for filtration, centrifugation or other tedious workup processes. In recent times, the catalytic potential of magnetically recoverable nanocatalysts was evaluated in synthesis of biologically active tetrazole derivatives. In this review, we focused on the fabrication, surface modification and characterization of nanomagnetite materials and their application as magnetically recoverable catalysts in the synthesis of biologically active tetrazole structural scaffolds.

四唑是重要的一类含氮杂环，在药物化学中具有广泛的应用。最近的文献研究清楚地表明，四唑具有广泛的生物学和药理活性，例如抗过敏，抗炎，抗溃疡，抗生素，降压，抗肿瘤，抗病毒和受体调节剂活性。可以通过使用外部磁体容易地将磁性可回收的纳米催化剂与反应介质分离，而不需要过滤，离心或其他繁琐的后处理过程。近年来，在生物活性四唑衍生物的合成中评价了磁性可回收的纳米催化剂的催化潜力。在这篇评论中，我们专注于制造，