Abstract

Both osteogenesis and anti-inflammatory bioactive materials play a vital role in the regeneration of skeletal defects. Bone inflammation is hard to cure and can lead to malformation or amputation. The purpose of this study is to use anti-inflammatory drugs to endow polyetheretherketone (PEEK) with the dual ability to achieve anti-inflammatory effects while maintaining favorable biocompatibility. In this experiment, the porous PEEK was immersed in an aspirin (ASP) solution after sulfonation, and the obtained porous PEEK had significantly improved the anti-inflammatory abilities. Additionally, grafting the bone forming peptide (BFP) onto the porous PEEK can distinctly enchance the osteogenesis capability. The effects of the BFP polypeptide on the proliferation of MC3T3-E1 cells and ALP activity, and the effects of aspirin on inflammation were systematically investigated. The modified material showed favorable biocompatibility and osteogenic ability. The results suggest that the combination of the BFP polypeptide with aspirin may lead to a synergetic effect on the stimulation of osteogenesis and on the reduction of inflammation.

摘要

成骨和抗炎生物活性材料在骨骼缺损的再生中起着至关重要的作用。骨骼炎症很难治愈，可能导致畸形或截肢。本研究的目的是利用抗炎药物赋予聚醚醚酮（PEEK）双重能力，在保持良好的生物相容性的同时达到抗炎作用。本实验中，将多孔PEEK磺化后浸入阿司匹林(ASP)溶液中，所得多孔PEEK的抗炎能力显着提高。此外，将骨形成肽 (BFP) 移植到多孔 PEEK 上可以明显增强成骨能力。BFP多肽对MC3T3-E1细胞增殖和ALP活性的影响，并系统地研究了阿司匹林对炎症的影响。改性材料显示出良好的生物相容性和成骨能力。结果表明，BFP 多肽与阿司匹林的组合可能对刺激成骨和减少炎症产生协同作用。