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Ethylcellulose microparticles enhance 3,3'-diindolylmethane anti-hypernociceptive action in an animal model of acute inflammatory pain.
Journal of Microencapsulation ( IF 3.9 ) Pub Date : 2020-09-01 , DOI: 10.1080/02652048.2020.1815882
Juliane Mattiazzi 1 , Marcel Henrique Marcondes Sari 1 , Paulo Cesar Oliveira Araujo 2 , Andrei Vinícius Englert 1 , Jéssica Mendes Nadal 3 , Paulo Vítor Farago 3 , Cristina Wayne Nogueira 2 , Letícia Cruz 1
Affiliation  

Abstract

Aim

The present work aimed at the DIM-loaded microparticles development and anti-hypernociceptive action evaluation.

Method

The formulations were prepared by O/W solvent emulsion-evaporation method and characterised by particle diameter, content and DIM encapsulation efficiency, drug release profile, thermal behaviour and physicochemical state. The anti-hypernociceptive action was evaluated in the animal model of acute inflammatory pain.

Result

The MPs had a mean diameter in the micrometric range (368 ± 31 μm), narrow size distribution, DIM content of 150 mg/g, encapsulation efficiency around 84% and prolonged compound release. Evaluations of the association form of DIM to MPs demonstrated the feasibility of the systems to incorporate DIM and increases its thermal stability. An improvement in the anti-hypernociceptive action of DIM was observed by its microencapsuation, because it was increased and prolonged.

Conclusion

Therefore, the MPs developed represent a promising formulation for oral administration of the DIM in the treatment of inflammatory pain.



中文翻译:

在急性炎症性疼痛的动物模型中,乙基纤维素微粒可增强3,3'-二吲哚基甲烷的抗痛觉过敏作用。

摘要

目标

目前的工作旨在加载DIM微粒的开发和抗痛觉过敏作用评估。

方法

通过O / W溶剂乳液蒸发法制备制剂,并通过粒径,含量和DIM包封效率,药物释放曲线,热行为和理化状态表征。在急性炎症性疼痛的动物模型中评估了抗痛觉过敏作用。

结果

MP的平均直径在微米范围内(368±31μm),尺寸分布窄,DIM含量为150 mg / g,包封效率约为84%,化合物释放时间长。对DIM与MP的关联形式的评估证明了该系统合并DIM的可行性,并提高了其热稳定性。通过微囊化,可以观察到DIM的抗痛觉过敏作用有所改善,因为它增加了并延长了时间。

结论

因此,开发的MP代表了一种用于治疗炎性疼痛的DIM口服给药的有前途的制剂。

更新日期:2020-10-02
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