Abstract

Five compounds (1–5), including three coumarins (1–3) and two alkaloids (4,5) were isolated during the first investigation of the stem bark of Aegle marmelos (L.) Corrêa. collected in Myanmar. Their structures were determined by NMR spectra analysis. Among them, 7´-O-ethylmarmin (1) and 2-O-ethyltembamide (5) were identified as new compounds. Skimmianine (4) showed moderate cytotoxicity against a HeLa cell line, and 7´-O-ethylmarmin (1), marmin (2), and (+)-epoxyaurapten (3) displayed weak radical scavenging activity according to a DPPH scavenging assay.

摘要

在对Aegle marmelos (L.) Corrêa茎皮的首次研究中，分离出五种化合物 ( 1 - 5 )，包括三种香豆素 ( 1 - 3 ) 和两种生物碱 ( 4 , 5 ) 。采集于缅甸。它们的结构由NMR光谱分析确定。其中，7´- O- ethylmarmin ( 1 ) 和2- O- ethyltembamide ( 5 ) 被鉴定为新化合物。Skimmianine ( 4 ) 对 HeLa 细胞系和 7´- O- ethylmarmin ( 1 )、marmin ( 2 ) 显示出中等的细胞毒性) 和 (+)-epoxyaurapten ( 3 ) 根据 DPPH 清除试验显示出弱的自由基清除活性。