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C-low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress
European Journal of Neuroscience ( IF 3.698 ) Pub Date : 2020-08-27 , DOI: 10.1111/ejn.14951
Susannah C. Walker 1 , Antonia Cavieres 2 , Valentín Peñaloza‐Sancho 2 , Wael El‐Deredy 3 , Francis P. McGlone 1, 4 , Alexies Dagnino‐Subiabre 2
Affiliation  

Affiliative tactile interactions buffer social mammals against neurobiological and behavioral effects of stress. The aim of this study was to investigate the cutaneous mechanisms underlying such beneficial consequences of touch by determining whether daily stroking, specifically targeted to activate a velocity/force tuned class of low-threshold c-fiber mechanoreceptor (CLTM), confers resilience against established markers of chronic unpredictable mild stress (CMS). Adult male Sprague Dawley rats were exposed to 2 weeks of CMS. Throughout the CMS protocol, some rats were stroked daily, either at CLTM optimal velocity (5 cm/s) or outside the CLTM optimal range (30 cm/s). A third CMS exposed group did not receive any tactile stimulation. The effect of CMS on serum corticosterone levels, anxiety- and depressive-like behaviors in these three groups was assessed in comparison to a control group of non-CMS exposed rats. While stroking did not mitigate the effects of CMS on body weight gain, CLTM optimal velocity stroking did significantly reduce CMS-induced elevations in corticosterone following an acute forced-swim. Rats receiving CLTM optimal stroking also showed significantly fewer anxiety-like behaviors (elevated plus-maze) than the other CMS exposed rats. In terms of depressive-like behavior, whereas the same velocity-specific resilience was observed in a forced-swim test and social interaction test both groups of stroked rats spent significantly less time interacting than control rats, though they also spent significantly less time in the corner than non-stroked CMS rats. Together, these findings support the theory CLTMs play a functional role in regulating the physiological condition of the body.

中文翻译:

C-低阈值机械传入靶向动态触摸调节慢性轻度应激大鼠的应激复原力

亲和的触觉互动缓冲了社会哺乳动物对压力的神经生物学和行为影响。本研究的目的是通过确定日常抚摸(专门针对激活速度/力调整的低阈值 c 纤维机械感受器 (CLTM) 类)是否赋予对已建立标记物的弹性,来研究触摸这种有益后果背后的皮肤机制慢性不可预知的轻度压力 (CMS)。成年男性斯普拉格道利大鼠暴露于 2 周的 CMS。在整个 CMS 协议中,每天以 CLTM 最佳速度 (5 cm/s) 或在 CLTM 最佳范围 (30 cm/s) 之外抚摸一些大鼠。第三个 CMS 暴露组没有接受任何触觉刺激。与未暴露于 CMS 的大鼠的对照组相比,评估了 CMS 对这三组中血清皮质酮水平、焦虑和抑郁样行为的影响。虽然抚摸并没有减轻 CMS 对体重增加的影响,但 CLTM 最佳速度抚摸确实显着降低了急性强迫游泳后 CMS 引起的皮质酮升高。与其他暴露于 CMS 的大鼠相比,接受 CLTM 最佳抚摸的大鼠也表现出明显更少的焦虑样行为(高架十字迷宫)。在抑郁样行为方面,而在强迫游泳测试和社交互动测试中观察到相同的速度特异性弹性,两组中风大鼠在互动上的时间明显少于对照大鼠,尽管它们在角落里的时间也明显少于非中风 CMS 大鼠。总之,这些发现支持了 CLTM 在调节身体生理状况方面发挥功能性作用的理论。
更新日期:2020-08-27
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