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Inactivation of HIF-prolyl 4-hydroxylases 1, 2 and 3 in NG2-expressing cells induces HIF2-mediated neurovascular expansion independent of erythropoietin.
Acta Physiologica ( IF 6.3 ) Pub Date : 2020-08-26 , DOI: 10.1111/apha.13547
Andrés A Urrutia 1, 2 , Nan Guan 1, 3 , Claudia Mesa-Ciller 2 , Aqeela Afzal 4 , Olena Davidoff 1 , Volker H Haase 1, 5, 6
Affiliation  

NG2 cells in the brain are comprised of pericytes and NG2 glia and play an important role in the execution of cerebral hypoxia responses, including the induction of erythropoietin (EPO) in pericytes. Oxygen‐dependent angiogenic responses are regulated by hypoxia‐inducible factor (HIF), the activity of which is controlled by prolyl 4‐hydroxylase domain (PHD) dioxygenases and the von Hippel‐Lindau (VHL) tumour suppressor. However, the role of NG2 cells in HIF‐regulated cerebral vascular homeostasis is incompletely understood.

中文翻译:

NG2 表达细胞中 HIF-脯氨酰 4-羟化酶 1、2 和 3 的失活诱导 HIF2 介导的神经血管扩张,而与促红细胞生成素无关。

大脑中的 NG2 细胞由周细胞和 NG2 胶质细胞组成,在执行脑缺氧反应中起重要作用,包括在周细胞中诱导促红细胞生成素 (EPO)。氧依赖性血管生成反应受缺氧诱导因子 (HIF) 调节,其活性由脯氨酰 4-羟化酶结构域 (PHD) 双加氧酶和 von Hippel-Lindau (VHL) 肿瘤抑制因子控制。然而,NG2 细胞在 HIF 调节的脑血管稳态中的作用尚不完全清楚。
更新日期:2020-08-26
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