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A Simple and Low-cost Poly (DL-phenylalanine) Modified Carbon Sensor for the Improved Electrochemical Analysis of Riboflavin
Journal of Science: Advanced Materials and Devices ( IF 7.382 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.jsamd.2020.08.005
N. Hareesha , J.G. Manjunatha

Abstract The current study reports on the electroanalysis of Riboflavin (RF) on the surface of a poly dl -phenylalanine modified carbon paste sensor (PDLPAMCPS). The developed sensor caused a noticeable electrocatalytic action for the redox activity of RF in a phosphate buffer solution (PBS) of pH 6.5. This analysis was evaluated using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) techniques. The active surface of the functioning sensor exposes well developed anodic peak with prominent electron transfer. PDLPAMCPS shows distinctive and improved DPV and CV peaks for RF with and without the presence of organic dyes and dopamine (DA). The impact of the solution pH, scan rate, accumulation potential and concentration on RF at PDLPAMCPS were studied. A vibrant linear growth was observed between the oxidation peak current and the RF concentration in the range of 6.0 μM–30.0 μM, which provides a lower limit of detection (LOD) of 92 nM with excellent sensitivity. The proposed method and sensor were applied for the assessment of RF in medicine sample as an analytical application with fine recoveries and low LOD.

中文翻译:

用于改进核黄素电化学分析的简单且低成本的聚(DL-苯丙氨酸)改性碳传感器

摘要 目前的研究报告了聚 dl-苯丙氨酸改性碳糊传感器 (PDLPAMCPS) 表面核黄素 (RF) 的电分析。开发的传感器在 pH 6.5 的磷酸盐缓冲溶液 (PBS) 中对 RF 的氧化还原活性产生了明显的电催化作用。该分析使用微分脉冲伏安法 (DPV) 和循环伏安法 (CV) 技术进行评估。功能传感器的活性表面暴露出具有显着电子转移的发育良好的阳极峰。PDLPAMCPS 在存在和不存在有机染料和多巴胺 (DA) 的情况下,对于 RF 显示出独特且改进的 DPV 和 CV 峰。研究了溶液 pH 值、扫描速率、累积电位和浓度对 PDLPAMCPS 处 RF 的影响。在 6.0 μM–30.0 μM 的范围内,在氧化峰值电流和 RF 浓度之间观察到了充满活力的线性增长,这提供了 92 nM 的检测下限 (LOD),并具有出色的灵敏度。所提出的方法和传感器被应用于药物样品中 RF 的评估,作为具有良好回收率和低 LOD 的分析应用。
更新日期:2020-12-01
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