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The Jekyll and Hyde of TREM2
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.tins.2020.08.002
Javier Rueda-Carrasco 1 , Soyon Hong 1
Affiliation  

In a recent paper, Gratuze et al. demonstrated a putative neuroprotective role of a key Alzheimer risk variant, TREM2R47H, against tau-mediated neurodegeneration in a mouse model of tauopathy. This study highlights the context-dependent response of microglia, and proposes antagonistic roles of TREM2 in Aβ- versus tau-mediated pathology.

中文翻译:

TREM2 的 Jekyll 和 Hyde

在最近的一篇论文中,Gratuze 等人。在 tau 蛋白病变小鼠模型中,证明了关键的阿尔茨海默病风险变异体 TREM2R47H 对 tau 介导的神经变性的推定神经保护作用。该研究强调了小胶质细胞的上下文依赖性反应,并提出了 TREM2 在 Aβ-与 tau 介导的病理学中的拮抗作用。
更新日期:2020-10-01
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