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Prebiotics, probiotics, fermented foods and cognitive outcomes: A meta-analysis of randomized controlled trials.
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2020-08-27 , DOI: 10.1016/j.neubiorev.2020.07.036
Wolfgang Marx 1 , Andrew Scholey 2 , Joseph Firth 3 , Nathan M D'Cunha 4 , Melissa Lane 1 , Meghan Hockey 1 , Melanie M Ashton 1 , John F Cryan 5 , Adrienne O'Neil 6 , Nenad Naumovski 4 , Michael Berk 7 , Olivia M Dean 1 , Felice Jacka 1
Affiliation  

This systematic review and meta-analysis aimed to evaluate randomized controlled trials that investigated the use of probiotic, prebiotic, and fermented food interventions for cognitive performance. In total, 22 studies (n = 1551) were included that investigated probiotics (11 studies, n = 724), prebiotics (5 studies, n = 355), and fermented foods (6 studies, n = 472). Despite several individual studies (14 of 22) reporting significant improvements in specific cognitive domains, results of the pooled meta-analysis found no significant effect for any intervention for global cognition (Probiotics: g = 0.115, 95 %CI -0.041, 0.270, p = 0.148; Prebiotics: g = 0.077, 95 %CI -0.091, 0.246, p = 0.369; Fermented food: g = 0.164 95 %CI -0.017, 0.345, p = 0.076) or any individual cognitive domain. Most studies (16 of 22) had low risk of bias. These results do not support the use of probiotic, prebiotic, and fermented food interventions for cognitive outcomes. This may be due to the limited number of small and short-term studies as well clinical heterogeneity relating to the population, cognitive tests, and intervention. Therefore, further trials that investigate these interventions in clinical populations using adequately powered samples are warranted. PROSPERO: CRD42019137936



中文翻译:

益生元,益生菌,发酵食品和认知结果:对随机对照试验的荟萃分析。

这项系统的综述和荟萃分析旨在评估随机对照试验,该试验研究了益生菌,益生元和发酵食品干预措施对认知功能的使用。总共包括22个研究(n = 1551),其中研究了益生菌(11个研究,n = 724),益生元(5个研究,n = 355)和发酵食品(6个研究,n = 472)。尽管有几项个体研究(22项中的14项)报告了特定认知领域的显着改善,但汇总荟萃分析的结果发现,对于任何全球认知干预措施均无显着影响(益生菌:g = 0.115,95%CI -0.041,0.270,p = 0.148;益生元:g = 0.077,95%CI -0.091,0.246,p = 0.369;发酵食品:g = 0.164 95%CI -0.017,0.345,p = 0.076)或任何单独的认知域。大多数研究(22个中的16个)偏倚风险低。这些结果不支持将益生菌,益生元和发酵食品干预措施用于认知结果。这可能是由于小型和短期研究数量有限,以及与人群,认知测验和干预措施相关的临床异质性。因此,有必要使用足够的能量样本对临床人群中的这些干预措施进行进一步的研究。PROSPERO:CRD42019137936

更新日期:2020-09-01
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